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Post by coachjm on Dec 19, 2015 9:46:34 GMT -6
I have been reading up on CTE and the research that has been done from several different resources. I'm curious if anyone has any links or knowledge of studies that have been done on Tau protein found in general population that were not involved in contact sports or military experiences. Also, is there a defined link between alzheimers and CTE, meaning do all alzheimers patients have the development of the tau protein or is their a belief that the CTE is a contributing link to other neurodegenerative issues?
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Post by Chris Clement on Dec 19, 2015 15:20:51 GMT -6
Nothing conclusive. We have a solid consensus that cumulative MTBI damage leads to issues later in life, but the in-between steps are kinda hazy.
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jmg999
Junior Member
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Post by jmg999 on Dec 20, 2015 18:32:47 GMT -6
I have been reading up on CTE and the research that has been done from several different resources. I'm curious if anyone has any links or knowledge of studies that have been done on Tau protein found in general population that were not involved in contact sports or military experiences. Also, is there a defined link between alzheimers and CTE, meaning do all alzheimers patients have the development of the tau protein or is their a belief that the CTE is a contributing link to other neurodegenerative issues? Everyone has tau proteins. What you're referring to are neurodegenerative disorders caused by the degeneration of tau proteins. Together, these neuropathologies, such as CTE, Alzheimer's, Parkinson's, etc, are called tauopathy. There are plenty of biological studies on tau proteins, unrelated to neurodegenerative disorders. As far as relation between these disorders is concerned, it's sort of a cascading effect, as one may lead to another, but in general, they affect different parts of the brain, so degeneration might start in one area, but it's possible that it could lead to another. |
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Post by coachjm on Dec 21, 2015 4:53:39 GMT -6
I have been reading up on CTE and the research that has been done from several different resources. I'm curious if anyone has any links or knowledge of studies that have been done on Tau protein found in general population that were not involved in contact sports or military experiences. Also, is there a defined link between alzheimers and CTE, meaning do all alzheimers patients have the development of the tau protein or is their a belief that the CTE is a contributing link to other neurodegenerative issues? Everyone has tau proteins. What you're referring to are neurodegenerative disorders caused by the degeneration of tau proteins. Together, these neuropathologies, such as CTE, Alzheimer's, Parkinson's, etc, are called tauopathy. There are plenty of biological studies on tau proteins, unrelated to neurodegenerative disorders. As far as relation between these disorders is concerned, it's sort of a cascading effect, as one may lead to another, but in general, they affect different parts of the brain, so degeneration might start in one area, but it's possible that it could lead to another. So are they identifying folks with CTE and taupathy in the general population specifically folks with Alzheimers/parkinson ect.? Also what is the effect of substance abuse on taupathy? I'm not trying to draw any conclusion as I know research is far from complete. It seems obvious to me that repeated head trauma is not a good thing for the brain and ultimately I feel this research is a good thing and necessary and I would love to pointed in the direction for additional articles and/or information specifically on the development of these diseases. |
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jmg999
Junior Member
Posts: 263
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Post by jmg999 on Dec 21, 2015 19:02:06 GMT -6
Everyone has tau proteins. What you're referring to are neurodegenerative disorders caused by the degeneration of tau proteins. Together, these neuropathologies, such as CTE, Alzheimer's, Parkinson's, etc, are called tauopathy. There are plenty of biological studies on tau proteins, unrelated to neurodegenerative disorders. As far as relation between these disorders is concerned, it's sort of a cascading effect, as one may lead to another, but in general, they affect different parts of the brain, so degeneration might start in one area, but it's possible that it could lead to another. So are they identifying folks with CTE and taupathy in the general population specifically folks with Alzheimers/parkinson ect.? Also what is the effect of substance abuse on taupathy? I'm not trying to draw any conclusion as I know research is far from complete. It seems obvious to me that repeated head trauma is not a good thing for the brain and ultimately I feel this research is a good thing and necessary and I would love to pointed in the direction for additional articles and/or information specifically on the development of these diseases. Think of it this way, the occurrence of lung cancer in the population of people who smoke one pack everyday for 20 years is much greater than in the population of those who don't smoke at all. However, it's still possible for someone who doesn't smoke to develop lung cancer. The question you seem to be asking is about the occurrences of lung cancer in the population who doesn't smoke. While it's certainly possible for CTE to develop in someone w/ minimal occurrences of head trauma, it's much more likely to occur in those who engage activities, which lead to repeated head trauma. Drug usage, as I'm sure that you're aware, leads to all sorts of cognitive impairment, often permanent, in the structure of the brain. There was a study performed a few years back, which linked recurrent opioid usage to a predisposition to Alzheimer-related symptoms at an earlier age. What they really found was an impairment in the hyperphosphorylization of tau, which is the process regulating mitosis, which, if you remember biology 101, is the process by which cells reproduction occurs during the totality of the cell cycle (Anthony, Norrby, Dingwall, Carnie, Millar, Arango, Robertson, & Bell, 2010). In other words, this breakdown can lead to chromosomal damage, which makes me wonder what effect this would have on future generations. Pregnant women would be at the greatest risk, I would imagine. Btw, I cited my source, since you said that you were interested in reading up on this further. Hope this helps, Coach. Anthony, I.C., Norrby, K.E., Dingwall, T., Carnie, F.W., Millar, T., Arango, J.C., Robertson, R., & Bell, J.E. (2010). Predisposition to accelerated Alzheimer-related changes in the brains of human immunodeficiency virus negative opiate abusers. Brain: A Journal of Neurology, 133, 3685-3698. doi: 10.1093/brain/awq263 |
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Post by coachjm on Dec 21, 2015 20:22:16 GMT -6
So are they identifying folks with CTE and taupathy in the general population specifically folks with Alzheimers/parkinson ect.? Also what is the effect of substance abuse on taupathy? I'm not trying to draw any conclusion as I know research is far from complete. It seems obvious to me that repeated head trauma is not a good thing for the brain and ultimately I feel this research is a good thing and necessary and I would love to pointed in the direction for additional articles and/or information specifically on the development of these diseases. Think of it this way, the occurrence of lung cancer in the population of people who smoke one pack everyday for 20 years is much greater than in the population of those who don't smoke at all. However, it's still possible for someone who doesn't smoke to develop lung cancer. The question you seem to be asking is about the occurrences of lung cancer in the population who doesn't smoke. While it's certainly possible for CTE to develop in someone w/ minimal occurrences of head trauma, it's much more likely to occur in those who engage activities, which lead to repeated head trauma. Drug usage, as I'm sure that you're aware, leads to all sorts of cognitive impairment, often permanent, in the structure of the brain. There was a study performed a few years back, which linked recurrent opioid usage to a predisposition to Alzheimer-related symptoms at an earlier age. What they really found was an impairment in the hyperphosphorylization of tau, which is the process regulating mitosis, which, if you remember biology 101, is the process by which cells reproduction occurs during the totality of the cell cycle (Anthony, Norrby, Dingwall, Carnie, Millar, Arango, Robertson, & Bell, 2010). In other words, this breakdown can lead to chromosomal damage, which makes me wonder what effect this would have on future generations. Pregnant women would be at the greatest risk, I would imagine. Btw, I cited my source, since you said that you were interested in reading up on this further. Hope this helps, Coach. Anthony, I.C., Norrby, K.E., Dingwall, T., Carnie, F.W., Millar, T., Arango, J.C., Robertson, R., & Bell, J.E. (2010). Predisposition to accelerated Alzheimer-related changes in the brains of human immunodeficiency virus negative opiate abusers. Brain: A Journal of Neurology, 133, 3685-3698. doi: 10.1093/brain/awq263 Absolutely awesome post and exactly what I was looking for! Thanks sooo much! |
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Post by fantom on Dec 21, 2015 20:46:17 GMT -6
Drug usage, as I'm sure that you're aware, leads to all sorts of cognitive impairment, often permanent, in the structure of the brain. There was a study performed a few years back, which linked recurrent opioid usage to a predisposition to Alzheimer-related symptoms at an earlier age. What they really found was an impairment in the hyperphosphorylization of tau, which is the process regulating mitosis, which, if you remember biology 101, is the process by which cells reproduction occurs during the totality of the cell cycle (Anthony, Norrby, Dingwall, Carnie, Millar, Arango, Robertson, & Bell, 2010). In other words, this breakdown can lead to chromosomal damage, which makes me wonder what effect this would have on future generations. Pregnant women would be at the greatest risk, I would imagine. Btw, I cited my source, since you said that you were interested in reading up on this further. Hope this helps, Coach. Anthony, I.C., Norrby, K.E., Dingwall, T., Carnie, F.W., Millar, T., Arango, J.C., Robertson, R., & Bell, J.E. (2010). Predisposition to accelerated Alzheimer-related changes in the brains of human immunodeficiency virus negative opiate abusers. Brain: A Journal of Neurology, 133, 3685-3698. doi: 10.1093/brain/awq263 Those guys played during the '70's when it was the Wild West as far as drugs go. Cocaine, quaaludes, there's no telling what those guys were taking. And steroids, those guys were literally experimenting with them -on themselves. |
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jmg999
Junior Member
Posts: 263
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Post by jmg999 on Dec 22, 2015 2:44:51 GMT -6
Drug usage, as I'm sure that you're aware, leads to all sorts of cognitive impairment, often permanent, in the structure of the brain. There was a study performed a few years back, which linked recurrent opioid usage to a predisposition to Alzheimer-related symptoms at an earlier age. What they really found was an impairment in the hyperphosphorylization of tau, which is the process regulating mitosis, which, if you remember biology 101, is the process by which cells reproduction occurs during the totality of the cell cycle (Anthony, Norrby, Dingwall, Carnie, Millar, Arango, Robertson, & Bell, 2010). In other words, this breakdown can lead to chromosomal damage, which makes me wonder what effect this would have on future generations. Pregnant women would be at the greatest risk, I would imagine. Btw, I cited my source, since you said that you were interested in reading up on this further. Hope this helps, Coach. Anthony, I.C., Norrby, K.E., Dingwall, T., Carnie, F.W., Millar, T., Arango, J.C., Robertson, R., & Bell, J.E. (2010). Predisposition to accelerated Alzheimer-related changes in the brains of human immunodeficiency virus negative opiate abusers. Brain: A Journal of Neurology, 133, 3685-3698. doi: 10.1093/brain/awq263 Those guys played during the '70's when it was the Wild West as far as drugs go. Cocaine, quaaludes, there's no telling what those guys were taking. And steroids, those guys were literally experimenting with them -on themselves. This study was unrelated to football. It was simply a population of HIV-negative opioid users. |
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